Negative emotion is associated with attentional biasing and narrowing, which impacts encoding. ![]() Second, a CBT treatment session is typically 50 min long, covers complex information, and can elicit negative emotion. First, even when memory is functioning optimally, fallibility is possible at initial encoding, storage or retrieval. We have offered various explanations for these findings. Also, poor memory for CBT is associated with poorer outcome. Perhaps not surprisingly, poor memory for the content of treatment is associated with poor adherence to medical treatments for chronic conditions, which is known to be associated with worse outcome. Recall is particularly poor for advice for health-behavior change. In one study, 25% of patients remembered recommendations that were not made. Patients accurately recall only about one third of the recommendations made during a physician visit and during a cognitive behavior therapy (CBT) session. If the results are promising, future directions will test the applicability to other kinds of interventions and disorders and in other settings. This study protocol describes a “next step” in the treatment development process by testing the Memory Support Intervention for major depressive disorder (MDD) and cognitive therapy (CT). The Memory Support Intervention has been developed to be “transdiagnostic” (relevant to a broad range of mental disorders) and “pantreatment” (relevant to a broad range of types of treatment). We will evaluate if previously reported poor treatment response subgroups moderate target engagement (aim 3). We will determine if patient memory for treatment mediates the relationship between treatment condition and outcome (aim 2). CT-as-usual to determine if the new intervention improves the course of illness and reduces functional impairment (aim 1). We will compare the effects of CT + Memory Support vs. ![]() Method/designĪdults with MDD ( n = 178, including 20% for potential attrition) will be randomly allocated to CT + Memory Support or CT-as-usual and will be assessed at baseline, post treatment and at 6 and 12 months’ follow-up (6FU and 12FU). As a “platform” for the next step in investigating this approach, we focus on major depressive disorder (MDD) and cognitive therapy (CT). ![]() The aim of this study protocol is to conduct a confirmatory efficacy trial to test whether the Memory Support Intervention improves illness course and functional outcomes. The Memory Support Intervention was developed in response to evidence showing that: (1) patient memory for treatment is poor, (2) poor memory for treatment is associated with poorer adherence and poorer outcome, (3) the impact of memory impairment can be minimized by the use of memory support strategies and (4) improved memory for treatment improves outcome.
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